|
Vitamin B6
|
3 mg
|
150
|
|
Melatonin
|
3 mg
|
**
|
Consult with your doctor before taking any nutritional supplements. These statements
have not been evaluated by the Food and Drug Administration. This information and product
is not intended to diagnose, treat, cure or prevent any disease. It is provided for educational
purposes only and is not intended as medical advice. If you have any concerns you should consult
with an appropriate health professional.
Details:
Melatonin is a hormone (N-acetyl-5 methoxytryptamine) produced especially at night in the pineal gland. The pineal is a key element in the maintenance of the body’s endocrine regulation (hormone balance), immune system integrity, and circadian rhythm (daily metabolic balance).The pineal gland functions as a biological clock by secreting melatonin (along with many other neuropeptides) at night. The pineal gland serves as the timekeeper of the brain, helping to govern the sleep-wake cycle and, in animals, seasonal rhythms of migration, mating, and hibernation. Secretion of melatonin is stimulated by the dark and inhibited by light. The secretion of melatonin follows a daily rhythm governed by the body's master clock. Melatonin levels are low during the day. At sunset, the cessation of light triggers neural signals which stimulate the pineal gland to begin releasing melatonin.
Melatonin is synthesized from the amino acid tryptophan. Tryptophan (l-tryptophan) is an essential amino acid formed from proteins during digestion by the action of proteolytic enzymes. Tryptophan is converted to serotonin and finally converted to melatonin which is an indole. The tryptophan during the day is converted into serotonin, a brain chemical involved with mood. Serotonin, in turn, is converted into melatonin. Synthetic melatonin and melatonin derived from bovine pineal glands are available as over-the-counter dietary supplements. Melatonin occurs naturally in some foods but in fairly small amounts. Of all the plant-based foods, oats, sweet corn and rice are richest in melatonin, containing between 1,000 and 1,800 picograms of melatonin per gram. Ginger, tomatoes, bananas and barley have about 500 picograms per gram. In the human population, melatonin levels are highest in children. Healthy young and middle-aged adults usually secrete about 5 to 25 micrograms of melatonin each night. The amount of melatonin the body secretes tends to decline with age, a possible link with an age-related rise in difficulty sleeping.
Melatonin has the ability to enhance or augment the function of the immune system. It seems to be capable of neutralizing the negative effects that stress, drugs and infections have on the function of the immune system. Melatonin secretion naturally drops off with age. This decrease is so reliable that blood melatonin levels have been proposed as a measurement of biological age. Melatonin, along with vitamin C and E, is an antioxidant and prevents oxidative damage. Melatonin also appears to inhibit tumor growth. Melatonin may be of value in untreatable metastatic cancer patients, particularly in improving their quality of life. Several studies indicate that Melatonin levels may be linked with breast cancer risk. Melatonin may enhance the effects of some chemotherapy drugs used to treat breast cancer. Administration of melatonin inhibits ovulation in humans by reducing luteinizing hormone concentrations. Melatonin supplements may benefit menopausal women by promoting and sustaining sleep. Melatonin levels may play a role in the symptoms of anorexia. Some interest has been shown in using melatonin in seasonal affective disorder (SAD), because the disorder is believed to be caused by the release of melatonin at an inappropriate time.