NAD Lozenges
Product ID: ES523
Description:
NAD (B-Nicotinamide Adenine Dinucleotide) is the biologically usable form of Niacin (Vitamin B-3). NAD is present in all living cells as a cofactor for many biochemical reactions, playing a central role in cellular energy production. Thus, the more NAD available to the cell, the more energy it can produce. NAD and its reduced form, NADH, are readily converted by the body, but unlike NADH, NAD is not altered by the acids present in the stomach.
Price: $15.00
Price shown is for one item per day for 30 days.
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| NAD (Nicotinamide Adenine Dinucleotide) | 25 mg | ** |
| Stevia Extract | 2.5 mg | ** |
| Niacin (as Nictinamide) | 4 mg | 20 |
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* Percent Daily Values (DV) are based on a 2000 calorie diet. ** Daily value not established |
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Consult with your doctor before taking any nutritional supplements. These statements
have not been evaluated by the Food and Drug Administration. This information and product
is not intended to diagnose, treat, cure or prevent any disease. It is provided for educational
purposes only and is not intended as medical advice. If you have any concerns you should consult
with an appropriate health professional.
Details:
In addition to its mood supporting properties, NAD is being studied with regards to its positive effects on naturally increasing the brain’s levels of dopamine, a neurotransmitter essential to brain health as we age.
INCREASING NAD WITH NICOTINAMIDE
Is there a way to increase NAD in the body? Fortunately, there is a direct precursor, the nutrient niacin (vitamin B3), in the form of either nicotinic acid or nicotinamide, which has a long history of use as a nutrient supplement.3 The result of one study showed that, although both of these compounds produce NAD, the rate of synthesis from nicotinamide is twice as great as that from nicotinic acid under physiological conditions. Moreover, the conversion was stimulated significantly by inorganic phosphate, but only for nicotinamide.
NAD AS NEUROPROTECTER
Other studies have shown that nicotinamide helps prevent DNA fragmentation. Independently of NAD's role, this can help protect mice from the oxidative stress associated with various neurodegenerative, age-related diseases. In one study, nicotinamide was found to produce neuroprotective effects via the elevation of NAD levels, which were increased by 50% in the mouse brain.4 It is believed that nicotinamide helps prevent the critical depletion of NAD, thus enabling it to repair DNA.
Apoptosis is a characteristic form of cell death (often called "cell suicide") that has been implicated in nerve degeneration. In another mouse study, apoptosis and DNA fragmentation were induced in vivo (in the body) by a potent free-radical neurotoxin that damages dopaminergic (motor-mechanism) neurons in the substantia nigra of the midbrain.5 Nicotinamide, again noted as a precursor of NAD, was able to block the induced apoptosis. As well, it was seen to quench some of the free radicals formed by xanthine oxidase.
Nicotinamide has also been found to help protect against DNA damage induced by radiation, especially when the cells to which it was directed were repair-deficient, but not so deficient as to be defunct.6
OLDER BECOME YOUNGER
The susceptibility to a strong chemical oxidant that causes DNA damage in most regions of the brain was found to be age-dependent.7 As measured by cell suicide (apoptosis), older mice (24 months) were found to have significantly more DNA damage than younger ones (8 months). This type of DNA-implicated nerve degeneration is observed in both Alzheimer's and Parkinson's disease patients. Nicotinamide was able to prevent DNA fragmentation damage when it was coadministered with the chemical toxin in older mice.
The nutrient nicotinamide enhances
the protective activity of Sir2p,
the longevity gene's protein.
Lymphocytes - white blood cells that fight infection and disease - from old mice show a lower level of DNA repair than lymphocytes from young mice.8 After in vitro (in a test tube) treatment with nicotinamide, UV-induced DNA repair was increased in resting lymphocytes from both young and old mice, but the effect was more dramatic in old mice, showing a twofold relative increase in repair. However, the presence of chemicals that inhibited the production of NAD limited DNA repair activity, demonstrating the importance of nicotinamide as a precursor of NAD and not some other substrate.
NICOTINAMIDE FOR DIABETES AND OSTEOARTHRITIS
In 56 recently diagnosed, insulin-dependent diabetic patients, 25 mg per kg of nicotinamide (2.0 g for a 175-lb individual) or a placebo was given over 12 months. The results showed that nicotinamide can be added to insulin in these patients to help prevent insulin-producing beta-cell destruction.9 Researchers currently believe that nicotinamide may be able to help prevent insulin-dependent diabetes in susceptible individuals10 (at least one trial is currently underway). This has been shown to be true in mice.11 Since the byproducts of diabetes help accelerate the aging process,12 it might be a good idea to take nicotinamide supplements as a preventive.
As a bonus, nicotinamide has been found to be beneficial in osteoarthritis and rheumatoid arthritis. A recent pilot study found nicotinamide to reduce erythrocyte sedimentation rate (the creation of red-blood-cell waste material) by 22% and increase joint mobility by 4.5 degrees, vs. controls.13 It also improved joint flexibility, reduced inflammation, and allowed for a reduction in standard anti-inflammatory medications.
NADH DOES NOT SIGNIFICANTLY BOLSTER NAD
The chemically reduced form of NAD, called NADH, has become popular as a supplement because studies have shown that it may be able to enhance brain and body functions for Alzheimer's disease, Parkinson's disease, and chronic fatigue syndrome. When the MIT researchers studied NADH, they found that it did not promote a significant level of gene-silencing by Sir2p, as did NAD. Apparently NADH diverts from some enzymatic step needed to amplify Sir2p's silencing effects.
INCREASING NAD WITH NICOTINAMIDE
Is there a way to increase NAD in the body? Fortunately, there is a direct precursor, the nutrient niacin (vitamin B3), in the form of either nicotinic acid or nicotinamide, which has a long history of use as a nutrient supplement.3 The result of one study showed that, although both of these compounds produce NAD, the rate of synthesis from nicotinamide is twice as great as that from nicotinic acid under physiological conditions. Moreover, the conversion was stimulated significantly by inorganic phosphate, but only for nicotinamide.
NAD AS NEUROPROTECTER
Other studies have shown that nicotinamide helps prevent DNA fragmentation. Independently of NAD's role, this can help protect mice from the oxidative stress associated with various neurodegenerative, age-related diseases. In one study, nicotinamide was found to produce neuroprotective effects via the elevation of NAD levels, which were increased by 50% in the mouse brain.4 It is believed that nicotinamide helps prevent the critical depletion of NAD, thus enabling it to repair DNA.
Apoptosis is a characteristic form of cell death (often called "cell suicide") that has been implicated in nerve degeneration. In another mouse study, apoptosis and DNA fragmentation were induced in vivo (in the body) by a potent free-radical neurotoxin that damages dopaminergic (motor-mechanism) neurons in the substantia nigra of the midbrain.5 Nicotinamide, again noted as a precursor of NAD, was able to block the induced apoptosis. As well, it was seen to quench some of the free radicals formed by xanthine oxidase.
Nicotinamide has also been found to help protect against DNA damage induced by radiation, especially when the cells to which it was directed were repair-deficient, but not so deficient as to be defunct.6
OLDER BECOME YOUNGER
The susceptibility to a strong chemical oxidant that causes DNA damage in most regions of the brain was found to be age-dependent.7 As measured by cell suicide (apoptosis), older mice (24 months) were found to have significantly more DNA damage than younger ones (8 months). This type of DNA-implicated nerve degeneration is observed in both Alzheimer's and Parkinson's disease patients. Nicotinamide was able to prevent DNA fragmentation damage when it was coadministered with the chemical toxin in older mice.
The nutrient nicotinamide enhances
the protective activity of Sir2p,
the longevity gene's protein.
Lymphocytes - white blood cells that fight infection and disease - from old mice show a lower level of DNA repair than lymphocytes from young mice.8 After in vitro (in a test tube) treatment with nicotinamide, UV-induced DNA repair was increased in resting lymphocytes from both young and old mice, but the effect was more dramatic in old mice, showing a twofold relative increase in repair. However, the presence of chemicals that inhibited the production of NAD limited DNA repair activity, demonstrating the importance of nicotinamide as a precursor of NAD and not some other substrate.
NICOTINAMIDE FOR DIABETES AND OSTEOARTHRITIS
In 56 recently diagnosed, insulin-dependent diabetic patients, 25 mg per kg of nicotinamide (2.0 g for a 175-lb individual) or a placebo was given over 12 months. The results showed that nicotinamide can be added to insulin in these patients to help prevent insulin-producing beta-cell destruction.9 Researchers currently believe that nicotinamide may be able to help prevent insulin-dependent diabetes in susceptible individuals10 (at least one trial is currently underway). This has been shown to be true in mice.11 Since the byproducts of diabetes help accelerate the aging process,12 it might be a good idea to take nicotinamide supplements as a preventive.
As a bonus, nicotinamide has been found to be beneficial in osteoarthritis and rheumatoid arthritis. A recent pilot study found nicotinamide to reduce erythrocyte sedimentation rate (the creation of red-blood-cell waste material) by 22% and increase joint mobility by 4.5 degrees, vs. controls.13 It also improved joint flexibility, reduced inflammation, and allowed for a reduction in standard anti-inflammatory medications.
NADH DOES NOT SIGNIFICANTLY BOLSTER NAD
The chemically reduced form of NAD, called NADH, has become popular as a supplement because studies have shown that it may be able to enhance brain and body functions for Alzheimer's disease, Parkinson's disease, and chronic fatigue syndrome. When the MIT researchers studied NADH, they found that it did not promote a significant level of gene-silencing by Sir2p, as did NAD. Apparently NADH diverts from some enzymatic step needed to amplify Sir2p's silencing effects.